A truck rollover on the Bruce Highway closed southbound lanes and caused delays into the afternoon peak on Wednesday afternoon.
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A semi-trailer tipped over at Murrumba Downs, north of Brisbane, spilling wood chips on the road.
Four other cars were also involved in the crash, with two people taken to hospital with chest pains.
At 2.30pm, southbound delays on the highway stretched back to Deception Bay.
Northbound traffic was banked up to Bald Hills on Gympie Arterial Road, while heavy traffic had built to Deagon Deviation on the Gateway Motorway.
Australian Traffic Network reporter Adam Smith said delays were likely to get worse during Wednesday night’s peak hour.
He said people travelling north on Gympie Arterial Road should head via Gympie Road to Strathpine, Petrie and Kallangur before trying to get onto the Bruce Highway.
Mr Smith recommended drivers on the Gateway Motorway to take the Deagon Deviation to the Redcliffe area before returning back to the highway.