With Brett Stewart (hamstring) facing two weeks on the sidelines and boom winger Tom Trbojevic set to miss six weeks with an ankle injury, the Sea Eagles have a long list of walking wounded following their Anzac Day victory over Newcastle.

Hooker Apisai Koroisau is in the most doubt after copping a hit to the ribs in the win against the Knights, however Matt Parcell, a late omission on the weekend, is back for this Saturday's clash against the Cowboys.

Manly won't train until the captain's run on Friday, with Lewis Brown (knee), Brayden Williame (knee), Steve Matai (shoulder) and Tom Symonds (shoulder) all racing the clock to take on the Cowboys at Brookvale Oval.

Former Cowboys winger Matthew Wright, who arrives at the club on Tuesday night after he was granted a release by North Queensland, could be thrown straight into the starting side to take on his former club.

Manly players had a day off on Tuesday, with massage and recovery on Wednesday, a day off on Thursday before their first and final training session on the eve of the match.

Meanwhile, Penrith has been dealt a blow with rookie five-eighth Te Maire Martin fracturing his scapula in the narrow loss to Cronulla last Sunday.

Martin had scans on the shoulder injury on Tuesday afternoon and is expected to miss eight weeks.

The injury to the New Zealand-born playmaker coincides with hooker James Segeyaro's return from a fractured arm, which is likely to see Peter Wallace switch from dummy half back to the halves alongside Jamie Soward.

The Panthers are also boosted by the return of centre Dean Whare, who was missed the past six weeks with a calf injury.

The Roosters welcome back halfback Mitchell Pearce from suspension for his Australia Day antics, while prop Jared Wearea-Hargreaves returns from injury to play his first game this season.

South Sydney halfback Adam Reynolds is expected to play on Thursday night against the Wests Tigers despite suffering what was originally feared as a broken jaw.

However, the Rabbitohs have lost centre Hymel Hunt for five months with a torn pec.

The Warriors have lost inspirational backrower Simon Mannering, who will miss this week's game against St George Illawarra after suffering a cut to his mouth in the loss to Melbourne.

Fullback Tui Lolohea, who picked up a knee injury in the same game, has been replaced at the back by David Fusitu'a.

A hamstring injury to Brisbane hooker Andrew McCullough will see Kodi Nikorima shift into the dummy half role, with Travis Waddell named on the bench.