The Queensland government's Executive Building, at 100 George Street, has been the seat of power since 1971 when it was opened by Sir Joh Bjelke Petersen.

The building has been a second home for nine premiers.

On Saturday, December 10 - also the state's Proclamation Day - a day of tours and talks will mark the blocky building's finale before it is demolished to make way for the $3 billion Queen's Wharf development.

Hosted half-hour tours will be held to the cabinet room, premier's offices, ground floor and media room from 10am to 4pm.

Information booths will also celebrate the past 45 years of Queensland political history.

It comes as the Queensland government began its last sitting week of 2016 with the first cabinet meeting in the new 1 William St building.

The final group of public servants moved in at the weekend, following weeks of staggered relocations from old government buildings,with about 4800 staff now working in the so-called 'Tower of Power'.

The cabinet meeting was preceded by a traditional indigenous smoking ceremony outside the foyer. 

In the new cabinet room, Premier Annastacia Palaszczuk told her ministers she needed everyone "100 per cent focused" for the last parliamentary sitting for 2016.

Queensland parliament is set to resume debate on the Serious and Organised Crime Legislation Amendment Bill this week.

Ms Palaszczuk described the bill as creating the most comprehensive serious and organised crime laws in Australia "if we get those laws through".

Leader of the House Stirling Hinchliffe said he was "sure we'll see a conclusion of that debate".

Labor's serious and organised crime laws would ride over the previous LNP government's Vicious Lawless Association Disestablishment laws.

Shadow Attorney-General Ian Walker has confirmed the LNP will not support the laws, which means their fate rests with the vote of the cross benchers.

Registration for the Executive Building tours is at www.executivebuildingfarewell.com.au