A woman was in critical condition after a two-vehicle crash on Lutwyche Road at Windsor.
Paramedics were called out at 3.15pm and treated two men for minor injuries and transported the Royal Brisbane and Women's Hospital.
The woman was in critical condition after being "significantly entrapped" in her vehicle.
The Forensic Crash Unit were attending the scene where the northbound lanes were blocked.
Police have closed off two northbound lanes and diverted one southbound lane.
Delays have been reported back to Fortitude Valley and motorists are being advised to avoid the area.