The increase in daily cases has not come as a surprise as the focus shifts to the number of people needing hospital or intensive care, Health Minister Yvette D'Ath said.

"I'm very pleased that all the people who have travelled from interstate are fully vaccinated ... and that means that these people are not showing signs of being seriously unwell," she said on Thursday.

Affected communities include Brisbane South, Brisbane north, Darling Downs, the Gold and Sunshine coasts, Townsville, West Moreton and Wide Bay.

Asylum Nightclub on the Gold Coast, The Brisbane Powerhouse and a train service on the Beenleigh line were among the exposure sites added to a growing list on Thursday.

Ms D'Ath is pleading with Queenslanders to resume wearing masks in indoor venues as Chief Health Officer John Gerrard warned there is an "active discussion" about a return to a mandate in certain settings.

"Now is the time to carry your mask and to start wearing that mask," Ms D'Ath said.

The warning comes as three previously announced cases were confirmed to have the Omicron variant, including a man who flew from Newcastle to Townsville via Brisbane.

The other two are a woman from Rochedale South who had also been in Newcastle and an international flight crew member who hadn't been out in the community.

Another four cases were confirmed in home and hotel quarantine on Thursday, bringing the total to 22.

Of the new cases, 12 are linked to interstate travellers, while one was locally acquired with the source a mystery.

Two infections were known contacts of existing cases on the Gold Coast and Darling Downs, and several are under investigation.

"We are identifying additional cases of Omicron hour by hour, so there will be more cases tomorrow," Dr Gerrard said on Thursday.

As well as lifting the vaccination rate, he reinforced calls for residents to wear masks indoors and on public transport.

"What we are aiming to do is to try and slow the spread of this virus to give people an opportunity ... to get the third dose of vaccine," he said.

"I have spoken to or every doctor that's looked after the patients with the Omicron virus, all of these have been vaccinated and for what it's worth all of these patients are well," he said.

While the sample size in Queensland is small, Dr Gerrard said it was a positive sign.

"It will be some weeks before we get good, solid clinical data from large numbers of people," he said.

The increase in case numbers comes with renewed concern about the level of vaccination rates among Queensland's Aboriginal and Torres Strait Islander residents.

As of December 7, less than 70 per cent of First Nations Queenslanders had received their first dose, well below the state average, a health services audit released on Thursday found.

"We are seeing First Nations vaccination rates go up quicker then our general population vaccination rates at the moment so that's a good thing," Ms D'Ath said.

The state has 67 active cases and the vaccination rate is at 89 per cent for first doses and 83.1 per cent double-dosed.

Australian Associated Press