The change, to apply from Monday, comes as SA Health reported 2047 new virus infections on Friday along with two more deaths.

Police Commissioner Grant Stevens said he was now confident the risks to officers and members of the community from the ongoing pandemic could be managed without the need for unvaccinated staff to be furloughed.

However, those officers will be required to take a rapid antigen test before starting work each day and wear a mask for the duration of their shift.

The change is expected to allow about 60 officers and about 18 other staff to return to their roles, subject to some limitations.

That includes their ability to attend high-risk settings such as aged care and disability facilities and the forensic science building.

Operational requirements would also be a factor with unvaccinated officers likely to be restricted from being deployed to venues with specific vaccine rules, such as Adelaide Oval.

Mr Stevens said vaccine mandates in other sectors, such as health, would be lifted when it was appropriate to do so based on regular reviews.

"Based on the review we've done, this is the appropriate time to lift this particular mandate," he said.

"We were considering our position for quite some time.

"I'm pleased that these people can come back to work. This is the right time for this to occur."

In Friday's update, SA Health said 106 people remained in hospital with COVID-19 including nine in intensive care.

One person is on a ventilator.

Active cases across SA stand at 18,363.

Premier Steven Marshall said while the state's daily case numbers would continue to "bounce around" the most important thing was keeping the number of people in hospital low.

"That's the number we're really focused on at the moment," he said.

Australian Associated Press