Fernandinho claims Manchester City's poor record at Anfield will count for nothing this weekend.
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The Premier League champions travel to current leaders Liverpool for an eagerly-awaited clash on Sunday.
Despite City's recent domestic dominance, they have been unable to break a long-running Merseyside hoodoo.
City have won just once at Anfield since 1981 - and that was 16 years ago.
Not even the arrival of Pep Guardiola as manager has brought a change of luck, with the Spaniard's four trips to the ground including a 3-0 Champions League quarter-final loss in 2018.
There is plenty riding on the latest meeting, with City looking to cut into the Reds' six-point lead at the summit.
"There's always a first time in the life, no? We are searching for this first time to win at Anfield," Fernandinho, who has been forced to reinvent himself as a defender this season due to injuries, said.
"We go there and try to win the game. The mentality is always try to win the game. I am confident we can go there and try to win."
Fernandinho believes City can build on the spirit shown in their hard-fought draw against Atalanta in the Champions League midweek.
City travelled to Milan looking for the victory that would secure their place in the last 16 but were forced to reassess on a night of goalkeeper chaos at the San Siro.
First-choice Ederson was forced off injured at halftime with a thigh injury and his replacement Claudio Bravo was sent off. City ended up hanging on for a 1-1 draw with right-back Kyle Walker in goal.
"In difficult situations like this we have to stick together and we did. This is important because we are building a team to be champions and sometimes to be champions you have to play games like this.
"We had to defend a little bit more than usual but Sunday we go there to try to win the game from the first minute," Fernandinho said.
Along with playmaker David Silva, who missed the trip to Italy with a muscular problem, Brazilian Ederson is doubtful for the weekend.
Australian Associated Press